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Karen Stewart and Kris Zurek R.N.M.H., ITEC, SNHS, Members of Microscopy Practitioners Association, Holistic Health Therapists

Holistic Health Centre,
Cloonloo, Boyle,
Co. Sligo.

Tel: 071 966 3311
Mobile: 087 972 8044

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Amazing Enzyme Serrapeptase

Serrapeptase – A Gift from Silkworms

The natural Chelator and Anti-Inflammatory enzyme Serrapeptase has had wide clinical use – spanning over twenty-five years throughout Europe and Asia – as a viable alternative to salicylates, ibuprofen and the more potent NSAIDs. Unlike these drugs, Serrapeptase is a naturally occurring, physiological agent with no inhibitory effects on prostaglandins and is devoid of gastrointestinal side effects.

To learn about health damaging effects of chronic inflammation (click here)

Scroll down to the bottom of the page to see Studies and Technical Information.

In the U.S., Serrapeptase is classified as a dietary supplement.


Review of SerraEnzyme:

As an avid gym user and someone who takes part in contact sports I got SerraEnzyme from Karuna Flame, as an anti inflammatory and pain killer on a knee injury and it has been very beneficial. I also had a severe injury to the ball of my foot which was left untreated. After 4 years of not being able to move my big toe due to scar tissue and being in severe pain, taking the recommended dosage of SerraEnzyme for 5 weeks I am now able to move my big toe freely and the pain is almost completely gone. SerraEnzyme in my opinion is an excellent product for treatment of sports injuries and natural pain relief. Take the dosage with plenty of water and on an empty stomach as recommended. I take mine in the morning a few hours before I eat, this works best for me.

Dean Kellett, Co. Westmeath

Check here for SerraEnzyme (brand name product containing high potency Serrapeptase)


Uses of Serrapeptase, it may help:

1. Atherosclerosis

Dr. Nieper found that Serrapeptase could dissolve blood clots and reduce varicose veins. Other studies from Germany have found that serrapeptase could effectively remove atherosclerotic plaque without hurting any of the healthy cells along the arterial wall.

2. Chronic Inflammation

Multiple studies confirm it’s resistance to inflammation and it has been used for this reason in the reduction of chronic sinusitis and other chronic or acute inflammatory conditions.

3.  Traumatic Injuries

Serrapeptase is widely used in Europe as a supplement for traumatic injury (such as sprains and torn ligaments), as well as the inflammation associated with post-surgical patients.

4.  Edema, Swelling and Pain

In many European countries, Serrapeptase has been approved as a standard remedy  for conditions involving inflammation and swelling. A double-blind study done in Germany found that the enzyme could reduce swelling by up 50% in post-operative patients. Patients taking serrapeptase enzyme experienced significant less pain than the control groups and, by the 10th day of the study, all patients taking the serrapeptase were completely pain free. (3,5,6,7)

5. Cystic Breast Disease

In a double-blind study, Serrapeptase was found to reduce breast pain and breast swelling in 85.7% of the patients taking the supplement. This is because the enzyme possesses fibrinolytic, proteolytic and anti-edemic properties. (2)

6. Infections in the Nose, Throat and Ear

In a double-blind study, patients with acute or chronic ear, nose or throat diseases found significant regression of symptoms with the use of Serrapeptase. The Serrapeptase enzyme was found to reduce the viscosity of mucous, leading to a facilitation of drainage. (4)

7.  Carpal Tunnel Syndrome

The most recent studies confirm the use of this anti-inflammatory enzyme for the reduction of symptoms associated with carpal tunnel syndrome. (2)

8. Other Potential Benefits

Serrapeptase is now being studied and used for a vast array of applications for human health and disease prevention. This includes therapeutic use for nerve damage, Multiple Sclerosis, chronic ear infections, hayfever, lung congestion, swollen glands, laryngitis, rhinitis, chronic pain, arthritis, back and neck pain, diabetes, ulcers, osteoporosis, prostate problems, rheumatoid arthritis, sports injuries (both prevention and recovery), post operative scars and lesions, varicose veins, arterial diseases, angina, blood clots, anti-aging, restoration of healthy fibrin metabolism and reduction in C-Reactive Protein.



  1. ‘The Miracle Enzyme’ – book authored by Robert Redfern, Nutritionist
  2. ‘The Miracle Enzyme’ – book authored by Robert Redfern, Nutritionist
  3. Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomized double-blind controlled trial. Singapore Med J. 1989:30(1):48-54.
  4. Mizukoshi, D. et al. A double-blind clinical study of serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979.
  5. Mazzonie, A. et al. Evaluation of serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind randomized trial versus placebo. J. int. Med. Res. 18(5):379-388,1990.
  6. Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
  7. Odagiri, J. et al. Clinical applications of serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979.
  8. Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-a prospective study (German). FortschrMed. 1989; 107(4):67-8, 71-2.

Check here for SerraEnzyme (brand name product containing high potency Serrapeptase)


Special Precautions & Warnings:

It is unlikely you can get any sensible advice from a healthcare provider unless they happen to have an expert understanding of enzymes and their function.

Bleeding disorders: You may have seen warnings on the internet claiming that serrapeptase may interfere with blood clotting and that some researchers worry that it might make bleeding disorders worse. We can categorically state that these warning are wrong and that the researchers have completely misunderstood the effects of serrapeptase. All serrapeptase does is to clear unhealthy inflammation and dead tissue.

Surgery: You may have seen warnings on the internet claiming that serrapeptase might interfere with blood clotting during and after surgery. Stop using serrapeptase at least 24 hours before a scheduled surgery. Restart 24-48hrs after the surgery depending how extensive the surgery is. This may help clear the scarring and help prevent lesions and adhesions.

Digestive Problems: It is not uncommon to get digestive discomfort or even pains from an unhealthy digestive tract when taking proteases. You can try adding a half teaspoon bicarbonate of soda to the glass of water to take with the serrapeptase. If this does not work and you have severe digestive problems then please call us to schedule appointment to design personal digestive recovery plan before restarting serrapeptase.

Interactions: There are no interactions with any drugs and that includes warfarin, statins and aspirin (which you should not need to take if taking serrapeptase).

One study documented a couple of rare side effect of pneumonitis (EG as noted in “A Case of pneumonitis due to serrapeptase” by Nihon Kyobu Shikkan Gakkai Zasshi in 1989). It is impossible to evaluate why these doctors made this claim and it may even have been because of tainted serrapeptase. Why? Because there are no other reports in over 20 years of use. Millions of doses have been recorded and thousands of sufferers of lung disease have taken serrapeptase with great success.